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生物电子等排
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生物电子等排
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生物电子等排
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bioisostere
生物电子等排
将化合物结构中的某些原子或基团,用其外层电子总数相等(同价)或在体积、形状、构象、电子分布、脂水分配系数,化学反应性和氢键形成能力等重要参数上存在相似性的原子或基团进行替换,产生新化合物的一种方法。
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