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nuclear receptor
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nuclear receptor
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细胞
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nuclear receptor
核受体
细胞内的转录因子超家族蛋白。类固醇激素、甲状腺激素等疏水性生物活性物质(即配体)通过特异性结合核受体,导致核受体变构激活。激活的核受体与DNA特异性顺式作用元件结合,启动下游靶基因的转录,从而参与调控生物体的分化、发育、代谢、稳态等过程。
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