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enhanced permeability and retention effect,EPR
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enhanced permeability and retention effect,EPR
Encyclopedia
医学
增强渗透与滞留效应
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enhanced permeability and retention effect,EPR
增强渗透与滞留效应
肿瘤组织为了满足快速生长的需求,血管快速生长,导致肿瘤新生血管缺乏外膜细胞,同时基底膜变形,形成肿瘤毛细血管壁的“缝隙”,一定粒径范围内的纳米微粒能穿透肿瘤毛细血管壁进入肿瘤组织内部;同时,肿瘤组织的淋巴回流系统不完善,造成纳米微粒在肿瘤部位蓄积的现象。
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